“The Stew Peters Network is proud to present DIED SUDDENLY, from the award winning filmmakers, Matthew Skow and Nicholas Stumphauzer. They are the minds behind WATCH THE WATER and THESE LITTLE ONES, and now have a damning presentation on the truth about the greatest ongoing mass genocide in human history.
The people have been lied to. It was a gigantic lie. And on this lie, everything that governments, especially in the Western democracies did to infringe on people’s rights, to take away their freedom, to lock them in their homes, imposing curfews, all of this was based on that gigantic lie.
Washington wanted to launch the Russia-Ukraine war in 2016, but then Trump got elected and it screwed up their plans.
David Icke Speaks the Truth
Mainstream Doctors and Scientists Face Censorship and Suppression for Dissenting COVID Views: Study
The study found “significant involvement of the media and the medical establishment in censorship and suppression of dissenters.”
The qualitative study, published by four Israelis and an Australian on Nov. 1 in the academic journal Minerva by Springer, included the subjective perceptions of 13 doctors and scientists from 7 countries: the United States, Canada, the UK, Australia, Germany, Israel, and the Czech Republic.
Nine participants hold an MD or a Ph.D. degree, and four hold both. Most of them are well-known in their fields, with proven research backgrounds and many academic publications. The participants remained anonymous.
The study found that COVID-19 censoring of doctors and researchers with flawless resumes and even senior academic or medical positions “has become a regular phenomenon.”
“The message is that no one is exempt from censorship and no academic or medical status, senior as it may be, is a guaranteed shield against it,” according to the study.
The study, called “Censorship and Suppression of Covid-19 Heterodoxy: Tactics and Counter-Tactics” found that both the media and medical authorities used a wide variety of censorship and suppressive tactics against the participants.
‘Derogatory Comments and Labels’
The media companies included both mainstream media and social media companies.
Tactics used by the media included “derogatory comments and labels, often using ostensibly independent ‘third-party’ sources such as anonymous ‘fact-checkers’ or other doctors, and online censorship involving the removal of their social media and internet contents and accounts,” according to the study.
Tactics used by medical authorities included “defamation and intimidation; retraction of scientific papers after publication; dismissal or adverse changes to employment contracts; aggressive actions aimed at sabotaging other significant roles of the individual, such as participating in important committees or serving as editors of scientific journals,” the study said.
Some of the participants reported being subjected to investigations and attempts to revoke their medical license in formal proceedings.
The participants believed that these tactics aimed to distract public attention from their message and deflect the discussion from their criticism or the allegations they raised.
The authors identified that the main limitation of the study is that the findings are based on subjective perspectives.
Dr. Robert Malone, one of the original inventors of the messenger RNA vaccine technology platform, called it a “stunning paper.”
“Having personally lived through what may be among the most intensive slander, defamation, and derision campaigns of the COVID crisis, none of what was described in this article surprised me,” wrote Malone on his Substack page.
The lead author, Yaffa Shir-Raz is a health journalist and risk communication researcher.
Shir-Raz obtained a leaked video from a source and publicly released clips from it beginning in mid-August. The video, a recording of an internal meeting in June of researchers commissioned by the Israeli Ministry of Health to analyze adverse event reports, revealed new information about side effects following COVID-19 vaccination.
Shir-Raz highlighted the case of Dr. Peter McCullough, a cardiologist in the United States.
A top medical board recently moved to strip McCullough, who has raised questions about the efficacy and safety of COVID-19 vaccines, of his certification.
McCullough, a former vice chief of internal medicine at Baylor University Medical Center in Texas and now the chief medical adviser for the Truth for Health Foundation, was previously banned by Twitter in early October.
“Twitter claimed that I violated the community rules after thousands of consistent posts on scientific abstracts, and manuscripts,” he told NTD’s “Capitol Report.”
McCullough said that he’s been providing updates on COVID-19 vaccines and related pandemic issues due to a feeling of responsibility.
“I felt I had the medical authority and professional responsibility to lead the nation. I’ve testified twice now in the U.S. Senate, multiple state Senates,” he said. “I’ve messaged the best I can through the peer-reviewed literature as well as with podcasts and now Substack formats.”
The Epoch Times confirmed that as of Nov. 7 McCullough remains banned on Twitter.
McCullough wrote on Gettr, a Twitter competitor, that the new study is an “unprecedented peer reviewed paper calling out censorship and reprisal by governments against clinical and academic physicians bringing the pandemic truth forward.”
Zachary Stieber and Steve Lance contributed to this report.
The Enemy is within
Huawei Lobbyist Gives Thousands to Democrats’ Midterm Campaigns
A lobbyist for a Chinese company deemed a national security threat has donated thousands of dollars to at least eight Democratic congressional campaigns.
Thomas Green, senior counsel at multinational law firm Sidley Austin and top lobbyist for Chinese telecom giant Huawei, personally contributed more than $10,000 across eight Democratic campaigns in the last month, according to data from OpenSecrets, a nonprofit group that tracks political spending.
The contributions were made primarily to Democratic campaigns in battleground states or where the Democratic contender was otherwise struggling.
The contributions included payments of $2,000 to Sen. Mark Kelly (D-Ariz.); $2,000 to Sen. Raphael Warnock (D-Ga.); $1,000 to North Carolina Supreme Court Chief Justice Cheri Beasley, who is running for a Senate seat; $1,000 to Wisconsin Lieutenant Governor Mandela Barnes, who is running for the Senate; $1,500 to Rep. Tim Ryan (D-Ohio), $500 to Glenn Ivey, who is running to represent Maryland in the House; $1,500 to Pennsylvania Lt. Gov. John Fetterman, who is running for a Senate seat; and $1,000 to Sen. Catherine Cortez Masto (D-Nev.).
Green has helped to lead Huawei’s lobbying team since 2019, when the company hired Sidley Austin to lobby for its interests in matters of export controls, trade, sanctions, and national security.
At that time, the Trump administration had restricted the company’s ability to do business with the U.S. government due to the company’s ties to the Chinese Communist Party (CCP) and apparent efforts to undermine U.S. foreign policy efforts.
Huawei was then charged in 2020 for conspiring to steal trade secrets from numerous U.S. technology firms and was ultimately declared a national security threat by the Federal Communications Commission in 2020.
The Biden administration launched another investigation into Huawei earlier this year, following reports that the company illegally used cell phone towers to collect information about U.S. military facilities in order to transmit that data to the CCP.
Additionally, the Justice Department announced several new cases last month alleging that CCP intelligence officers attempted to interfere with the case against Huawei on behalf of the Chinese regime and for the benefit of the company.
According to court documents (pdf), the Chinese agents attempted to illegally torpedo the case against Huawei by bribing a U.S. government employee to steal top secret documents including witness lists, details on employees associated with the case, and prosecutors’ notes, which, according to court documents, were “expected to cause serious damage to the national security of the United States.”
Green also defended former Trump aide Rick Gates, who pleaded guilty in 2019 to evading taxes and violating federal lobbying laws by concealing millions of dollars from business dealings in Ukraine.
The news is just the latest in a growing list of accusations against prominent Democrats with alleged ties to the CCP.
Rep. Don Beyer (D-Va.) was forced to fire a congressional aide last month after an investigation found the employee had attempted to set up meetings with members of Congress at the request of the Chinese embassy in Washington.
Michigan Governor Gretchen Whitmer, meanwhile, was accused last month of delivering $715 million in taxpayer monies to the U.S. subsidiary of a Chinese company with deep links to the CCP. Whitmer defended the move as “economic development.”
The Epoch Times has requested comment from Green and all Democratic campaigns that received the funds.
Dr Peter McCullough fighting the Corrupt medical board who wants to suspend his license for speaking out against the Vaccine
And We Know
Leaked Hospital Memo Reveals 500 Percent Rise In Stillbirths; Fetal Specialist Explains Likely Cause
“Last week, a hospital memo was leaked to us by a nurse in Fresno (https://www.theepochtimes.com/t-fresno), California (https://www.theepochtimes.com/t-california). The note revealed how this hospital is experiencing a dramatic rise in the number of stillbirth cases. Whereas before, the hospital would see an ‘average of one to two every three months’—they were now seeing upwards of 22 stillbirths per month.
This leaked anecdote seems to align with other anecdotal evidence across the country, showing a potential rise in problems with fertility, miscarriages, and fetal development.
And so, in order to get a clearer picture of what is happening, and why, we spoke with Dr. James Thorp, a Florida-based OB-GYN who specializes in maternal-fetal medicine.”
Aborted Fetus Cells Products in our food and drinks
Dr James Thorp: “We are talking about birth rates declining all over the world, my main concern with these babies is VAIDS; these babies do not have a normal immune system…”It’s a bloody disaster”.
Dr. Mike Yeadon Names Names: ‘You Are Responsible’ for Crimes Against Humanity
Human Bodies Scanned At Airports for Luciferase Proof of Vaccination
“Religious groups want more souls on the planet” “I want Less Souls On The Planet”
Officials Across United States Spread Misinformation on COVID-19 Vaccines
Officials across the United States are continuing to spread misinformation about COVID-19 vaccines, The Epoch Times has found.
The claims include unsupported or misleading statements about vaccine effectiveness and safety.
The vast majority of officials responsible for the misinformation were unable or unwilling to provide evidence backing their claims.
The Louisiana Department of Health is among those exaggerating vaccine effectiveness. The agency claims in a promotional message that the vaccines “are 100% effective at preventing serious hospitalizations and deaths.”
The message does not cite any evidence and the department did not respond to a request for comment.
Clinical trials for the Moderna and Pfizer vaccines estimated effectiveness against severe illness at 100 percent, but studies since then have shown the protection starts much lower and drops quickly. That’s led to the clearance and recommendation of boosters, which confer a boost that also wanes.
Louisiana’s statement is one of many that rely on data from 2021, before the Omicron virus variant emerged, or even 2020. That data has little connection with the present state of the pandemic.
South Dakota’s health department, meanwhile, says that “Nearly everyone in the United States who is getting severely ill, needing hospitalization, and dying from COVID-19 is unvaccinated.”
That’s not true, and hasn’t been for months.
South Dakota officials did not return an inquiry.
Such statements are “directly related” to the drop in public confidence in health authorities during the pandemic, Dr. Jay Bhattacharya, a professor of medicine at Stanford University, told The Epoch Times after reviewing a sample of the claims.
“The public understands when they’re being manipulated,” he added.
Hyping Vaccines for Children
Many state health agencies are offering falsehoods about COVID-19 vaccine safety and effectiveness, or downplaying negative information about the shots—a continuation of a trend that dates back to when the vaccines became available in late 2020.
One theme emerged over the summer—hyping vaccine effectiveness for young children after U.S. authorities authorized and recommended the Pfizer and Moderna shots for children aged 6 months to 5 years.
“We welcome having COVID-19 vaccines to help protect our youngest Marylanders against severe illness, hospitalization, or even death from this virus and strongly encourage parents to vaccinate their children,” Maryland Health Secretary Dennis Schrader said in a statement.
“Clinical trials proved that the pediatric vaccine is an effective way to prevent COVID infection and serious illness in young children,” the Massachusetts Department of Public Health says on its website.
But the clinical trials for the age group weren’t able to measure efficacy against severe illness, which has been acknowledged by the U.S. Centers for Disease Control and Prevention (CDC).
“The clinical trials were not powered to detect efficacy against severe disease in this young population,” Dr. Sara Oliver, a CDC medical officer, told a meeting over the summer.
Saying the vaccines protect young children against severe disease “is a leap of faith,” Dr. David McCune, a hematology and oncology doctor in Washington state, told The Epoch Times. “It’s not supported by the research.”
Officials in every state were asked to provide evidence for dubious or false statements. Maryland officials pointed to a CDC page that did not support Schrader’s statement. Massachusetts officials did not respond to an inquiry.
False Statements on New Boosters
The U.S. Food and Drug Administration (FDA) recently authorized updated booster shots from Moderna and Pfizer. The CDC then recommended them for virtually all Americans aged 12 and older, and later enabled children 5 to 11 to get one of the new shots.
Clinical trials for the bivalent boosters, which contain spike protein components targeting the original COVID-19 strain and the BA.4/BA.4 Omicron subvariants, were not done—and have not been completed—on any group of humans as of yet.
Officials relied on data from testing in mice, data from the original vaccines, and a BA.1/Wuhan bivalent that has never been available in the United States.
The testing on that bivalent, done in adults 18 and older (Moderna) and adults 55 and older (Pfizer), showed that the updated boosters triggered higher levels of antibodies than the old boosters. But the trials didn’t provide any efficacy estimates for protection against infection or severe illness.
The dearth of data didn’t stop states from promoting the vaccines as tools that would definitely work.
“Adding a component to the boosters that specifically targets the subvariants currently circulating will help restore protection against COVID-19 infections, including hospitalizations, that has decreased over time,” Dr. Dean Sidelinger, Oregon’s state epidemiologist, said in a statement.
“The updated bivalent COVID-19 booster, along with the flu vaccine, give parents two powerful tools to protect their children from severe illness and hospitalization,” Dr. Sameer Vohra, the director of the Illinois Department of Public Health, said.
Officials in Oregon and Illinois did not respond to requests for comment.
Minimizing Side Effects
Many states emphasize how most side effects are mild. That’s true, according to data from the CDC and studies. But a number of states fail to mention serious side effects, like heart inflammation, that have been linked to the vaccines.
New York, Pennsylvania, and South Carolina, for instance, didn’t mention myocarditis, a form of heart inflammation, or thrombosis with thrombocytopenia syndrome (TTS), a severe blood clotting issue.
Most of the states that did mention myocarditis promoted the idea that the incidence of myocarditis is higher after COVID-19 infection than after COVID-19 vaccination.
“Myocarditis and pericarditis are much more common if you get sick with COVID-19,” the Washington state Department of Health says on its website.
“The risk of developing myocarditis after a COVID-19 infection is much higher than the risk of developing myocarditis after the vaccine,” the Alabama Department of Public Health said in a press release over the summer.
But more papers show a higher rate of myocarditis after vaccination in high-risk groups, especially young men, including one provided by authorities in Alabama.
Asked for evidence for its statement, Alabama officials sent a link to a British study published after its release was issued. But the study detected a higher risk for young males, or men aged younger than 40 years old, after vaccination.
After that was pointed out, Alabama officials stopped responding.
Some states, like Oregon, say no deaths have been linked to myocarditis after COVID-19 vaccination. Researchers around the world, including with the CDC, have determined there’s a causal link between myocarditis and the Pfizer and Moderna vaccines, which both utilize messenger RNA (mRNA) technology. And autopsies and medical records have confirmed deaths from myocarditis among the vaccinated.
TTS is an often-fatal form of blood clotting that happens on occasion after receipt of the Johnson & Johnson vaccine, according to federal officials. The FDA restricted the Johnson & Johnson vaccine due to TTS.
Dr. Danice Hertz, who was injured by a vaccine, says that the statements underline her experience with the health care system and top federal officials. That includes the FDA not acknowledging how many Americans have actually been injured by one of the shots.
“I blame the FDA and our federal government for creating this environment where doctors don’t know anything about vaccine injuries,” she said.
A number of states still cite data from 2021 or even 2020, even though over half a dozen new variants have emerged since COVID-19 first appeared.
“FDA-authorized COVID-19 vaccines protect against Delta and other known variants,” the Oklahoma State Department of Health says on its website.
The Delta variant stopped circulating in the United States in 2021.
Oklahoma also says that so-called breakthrough cases, or post-vaccination infections, “happen in only a small percentage of vaccinated people.”
That hasn’t been true since Omicron displaced Delta in late 2021.
The California Department of Public Health links to a study from the CDC that was published in August 2021 when claiming that unvaccinated people who already had COVID-19 “are more than twice as likely as vaccinated people to get it again.”
Studies from late 2021 and 2022 show that post-infection protection, known as natural immunity, is superior to vaccination. Natural immunity has also held up better, but also waned against newer variants.
Heavy Reliance on the CDC
Nearly all of the state health agencies rely heavily on the CDC and other federal agencies.
Many repeatedly reference the CDC on their websites. The CDC has promoted misinformation on COVID-19 vaccines during the pandemic, including the unsupported claim that the vaccines protect young children against severe illness and promoting a study that exaggerated the COVID-19 death toll among children.
States that did provide evidence to back claims mostly cited CDC studies and documents.
The CDC publishes a quasi-journal called the Morbidity and Mortality Weekly Report. The CDC has said (pdf) the publication is distinct from “all other health-related publications,” in part because the content “constitutes the official voice” of the CDC and because most articles are not peer-reviewed. Instead, multiple levels of CDC officials review a submission.
“By the time a report appears in MMWR, it reflects, or is consistent with, CDC policy,” the CDC said in one overview of the publication.
The CDC and its partner, the FDA, have aggressively promoted vaccination during the pandemic, even when little evidence supports the vaccines. The agencies have also repeatedly refused to release COVID-19 vaccine safety data.
Dr. Todd Porter, a pediatrician in Illinois, said that the effort to get virtually all children vaccinated against COVID-19, despite the small amount of efficacy and safety data, is contributing to parents hesitating over other vaccines.
“This has created a much different conversation with parents of my patients with respect to benefit/harm and has further eroded parent confidence in public health and has made it harder for me to make recommendations for other more important proven vaccines,” Porter told The Epoch Times in an email. “Most notable has been lack of influenza vaccine uptake in my patients over the past year.”
Regaining people’s trust is key to moving forward and involves acknowledging information that was conveyed is not correct, experts said.
“When a public health authority or federal official says something that’s incorrect, it has a responsibility to correct it. And when it doesn’t, when it just lets the matter lie, people continue to distrust them even more,” Bhattacharya said.
One example, he said, is how officials repeatedly said—and some are still saying—that the vaccines cut down on transmission, even though a top Pfizer executive recently acknowledged testing on transmission has not been done. The claim that vaccines curb transmission helped lead to vaccine mandates.
“I think it would go a long way if our nation’s public health institutions could demonstrate humility and acknowledge that in the panic of the pandemic they got it wrong where it comes to children,” Porter said.
The urge to get people vaccinated has led to some of the false and misleading claims, according to McCune, who saw the same pattern repeated during the rollout of the new boosters.
“You could have started with the bivalent booster and said, ‘this is what we know. We know some things about antibody levels from basic science studies that were done in animal models and from similar vaccines that were given to humans that we have a reason to believe these antibodies are going to improve,’” he said. “And then to say, ‘the reason we were approving this is we think that this has overall been a safe program, and we don’t anticipate there’ll be future problems. We’re making a leap here to try and get ahead of it, even though there’s some uncertainty.’ That’s an honest statement, but it’s not a very salesy statement.”
McCune foresees it taking years to rebuild trust in public health, and believes it will require changes at both the CDC and FDA.
REAL AMERICA – Dan Ball W/ Joseph Vasquez, Google Caught Tampering With Search Results, 10/26/22
Lora Logan talks about Child Trafficking
FBI Investigating Itself
Natural Ways to Increase Autophagy and Detox Spike Proteins After COVID Infection, Vaccination
At least 10 to 30 percent of individuals infected by SARS-CoV-2 have experienced post-COVID syndrome (also known as long-hauler syndrome, or long COVID). In the United States, 18 to 19 percent (nearly 1 in 5) of adults who reported ever having had COVID-19 currently have symptoms of long COVID, defined as symptoms lasting three or more months that were not present prior to having COVID-19.
“Post-COVID-vaccine syndrome,” a newly coined term by Dr. Paul Marik, is defined as the temporal correlation between receiving a COVID-19 vaccine and the beginning or worsening of clinical manifestations which are sufficient to diagnose a COVID-19 vaccine-induced injury when symptoms cannot be explained by other concurrent causes.
Both types of diseases have contributed to the fact that 8 percent (nearly 1 in 13) of U.S. adults, regardless of prior COVID-19 infection, currently have post-COVID-like conditions.
As a matter of fact, there are significant overlaps between long COVID and post-vaccine syndromes. Both are systemic, chronic diseases characterized by immune dysregulation, inflammation, fatigue, and declined functions of multiple vital organs, including at least the brain, heart, lungs, and endocrine organs.
According to a systematic review published in 2022 involving 1,680,003 COVID-19-positive patients from 50 studies, among the top 18 frequent symptoms of long COVID, 50 percent of them are neuropsychiatric, including brain fog, memory problems, sleep disorder, anxiety, depression, smell or taste disorders, dizziness, and headaches.
Of all the post-marketing adverse events reported by Pfizer on its COVID vaccine, neurological disorders rank second, just behind “general disorders,” followed by musculoskeletal, gastrointestinal, and respiratory issues.
These clear similarities between long COVID and COVID vaccine-induced injuries indicate that they share common pathological features as well.
Persistent Spike Protein Causes Persistent Immune Dysregulation
The spike protein-induced dysregulated inflammatory state and subsequent multiple organ damage, or proposed “spikopathy,” is indeed one of the most fundamental injuries of both syndromes.
Researchers have proven that the spike protein decreases natural killer (NK) cells and inhibits their activity. This means that the spike protein itself is able to compromise innate antiviral immunity, exhausting NK cells’ functions.
Scientists found that the spike protein could be detected in the blood mononuclear cells of long COVID patients for up to 15 months post-infection. This is associated with abnormal types of monocytes, which were presumed to be a major source of triggering chronic inflammation.
Furthermore, the SARS-CoV-2 virus can interfere with the cellular recycling process known as autophagy.
What is autophagy? Why is it important?
Autophagy: Human Self-Renewal and Self-Cleaning Process
The process of getting rid of waste or toxins from cells is called autophagy.
The concept of autophagy was first introduced in 1974 by Belgian cytologist and biochemist Christian de Duve. He was awarded the Nobel Prize in Physiology or Medicine in the same year for his discovery of lysosomes.
Literally, autophagy means “self-eating.” It is a natural physiological mechanism wherein dysfunctional cells are broken down and their waste products are used to make healthy cells, similar to a city’s waste recycling process.
During the process of autophagy, an autophagosome is first produced in the cell and then acts as a “garbage bag,” enveloping the various waste products in the cell. The “garbage bag” will fuse with a lysosome (which contains loads of enzymes to break down the garbage) to form a “garbage processing station” called an autolysosome, which will then break down and recycle the waste materials.
Once autophagy is initiated, cytoplasmic elements, or the “cargo” that is to be recycled, are engulfed into double-membrane vesicles, termed autophagosomes, which fuse with lysosomes to form autolysosomes, where the cargo is then degraded.
Autophagy is an important physiological mechanism that not only removes harmful components from cells in a timely manner but also transforms useless proteins into recyclable amino acids.
This brings a variety of benefits to the body, including anti-aging benefits, reduced inflammatory status, boosted immunity, and reduced cancer risk.
It is likely that autophagy removes spike proteins as well as misfolded proteins induced by the spike proteins themselves. Autophagy may therefore play a critical role in reversing the “spikopathy” induced by the virus and COVID injections. Indeed, activation of autophagy is one of the most pivotal mechanisms for removing intracellular spike proteins.
How does SARS-CoV-2 impair autophagy?
A component of the SARS-CoV-2 virus (ORF3a) inhibits the cells’ waste-recycling process. The virus also impairs autophagy by reducing glycolysis and protein translation by limiting the activation of AMP-protein activating kinase (AMPK) and mammalian target of rapamycin complex 1 (mTORC1).
In cells infected with the SARS-CoV-2 virus, the formation of autolysosomes (“garbage processing stations”) has been substantially blocked, resulting in many more “garbage bags” of cellular waste accumulating inside the cells, while at the same time reducing the cells’ processing ability, preventing the timely recycling of waste and harmful substances in the cells. This further worsens the persistence of spike proteins in our bodies and cells.
With the majority of the world’s population having been vaccinated due to policies that were put in place, it is estimated that most patients with long COVID are likely also vaccinated. This could make the symptoms of long COVID patients more complicated.
Healthy Lifestyles Boost Autophagy
As the majority of the disorders are directly or indirectly caused by the spike protein of the virus, one of the most important treatment strategies is to help eliminate the spike protein from our cells.
The most powerful way to boost our autophagy process resides with our lifestyles. For example, how much and how often do we eat? Do we go to sleep on time and get quality sleep? Do we go outside regularly to enjoy the sun? All these correlate to the level of autophagy inside our bodies.
Food has been considered a means of providing nutrients to people. Most people consume three meals a day, but perhaps few have the thought that three meals per day may not be necessary.
In fact, we can live even healthier if we eat a little less. Why?
After meals, our gut absorbs glucose, amino acids, and fatty acids to be used as the main sources of energy and nutrients by our cells.
During fasting, the reduced amount of glucose and amino acids downregulate a molecular pathway (called mTOR) and subsequently up-regulates autophagy.
Short-term fasting leads to a dramatic upregulation in autophagy. The increased neuronal autophagy is revealed by changes in autophagosome abundance, and by diminished neuronal mTOR activity in vivo.
Mechanistically speaking, stimulating the clearance of damaged cells (autophagy), damaged mitochondria (mitophagy), and misfolded and foreign proteins has a profound effect on promoting immune system homeostasis, improving mitochondrial health, and boosting neuroregeneration.
Preclinical studies have shown robust evidence that intermittent fasting has broad-spectrum benefits for many health conditions, such as obesity, diabetes mellitus, cardiovascular disease, cancers, and neurologic disorders.
Clinical trials of intermittent fasting have shown improved verbal memory, working memory, and cognitive function. This is mainly contributed by the enhanced autophagy processes that help neuronal cells clear their waste more efficiently.
Fasting also triggers the breakdown of triglycerides, resulting in increased levels of free fatty acids (FFA), which subsequently generate more ATP as well as more proteins beneficial for neuroregeneration (brain-derived neurotrophic factor, and fibroblast growth factors, etc).
Accordingly, fasting-induced activation of autophagy has been proposed to be a promising tool for host defense against SARS-CoV-2 and vaccine-related multiple systemic symptoms, including neurological (brain fog), as well as symptoms caused by dysregulated immune function.
Intermittent fasting restores autophagic flux in islet cells and improves glucose tolerance by enhancing glucose-stimulated insulin secretion, beta cell survival, and pancreatic regeneration via activating the autophagy-lysosome pathway.
A number of intermittent fasting plans can be adapted and modified to best suit the patient’s lifestyle. For timed fasting, begin slowly: start with a 10-hour eating window 5 days a week, and then reduce weekly to reach the goal of an 8-hour eating window 7 days a week.
Intermittent fasting/timed restricted eating needs to be coupled with a diet that consists of “real food,” minimizing the intake of processed foods.
Note that fasting is contraindicated in patients younger than 18 (due to impaired growth), malnourished patients (BMI < 20 kg/m2), and during pregnancy and breastfeeding.
Patients with diabetes, gout, or those with serious underlying medical conditions should consult their primary care physician prior to undertaking to fast, as changes in their medications may be required, and these patients require close monitoring.
It is important to stay well-hydrated during fasting periods; drink lots of water and/or an electrolyte solution.
Intermittent fasting represents a simple, safe, and inexpensive means to benefit people and free them from a variety of symptoms. As Mark Twain (1835–1910) once remarked, “A little starvation can really do more for the average sick man than can the best medicines and the best doctors.”
Sunlight, Near-Infrared Radiation, and Photobiomodulation
Sunlight has great healing powers. Our forefathers roamed the earth and were exposed to sunlight on a daily basis, likely leading to profound health benefits.
During the 1918 influenza pandemic, “open-air treatment” appeared to be the most effective treatment for seriously ill patients. The importance of sunlight and copious amounts of fresh air in self-healing appears to have substantially reduced deaths among patients.
Studies have shown that exposure to sunlight may alleviate multiple conditions, including myocardial infarction, depression, bipolar disorders, premature babies with jaundice, and stress and pain after surgery.
A large prospective study in Swedish melanoma patients has demonstrated that the all-cause mortality rate amongst those who avoid sun exposure was approximately two-fold higher compared to the group with the highest sunlight exposure.
Most people may believe that the main benefits of sunlight come from UV radiation stimulating vitamin D synthesis. However, beyond vitamin D, there are multifactorial and related benefits with photobiomodulation by red and near-infrared light. Red and near-infrared (NIR) radiation have a profound effect on human physiology, notably acting as a mitochondrial stimulant, increasing ATP production.
Amongst all the waves in sunlight, near-infrared radiation (NIR-A) with a spectrum of 750-1500 nanometres has the deepest penetration into tissues, reaching up to 23 centimeters deep.
Furthermore, NIR light increases the production of melatonin in mitochondria, which thus increases autophagy, as described above.
The increased body temperature induced by NIR-A and NIR-B also activates the production of heat shock proteins (which increase autophagy) and essential cell stress survival pathways.
“Yesterday I heard from a patient who was almost completely bedridden due to long COVID. She bought an infrared sauna and says it resurrected her life. She can now work and look after her child,” said Dr. Marik.
Quality and Timely Sleep
There are three main reasons why sleep is important for autophagy.
First, most of our brain-based autophagy happens during the night when we’re in deep sleep. Autophagy has a rhythm just like our human body, and it is optimized when we align our internal rhythm with the sun’s cycle around the earth.
Second, autophagy also happens during sleep because when we sleep, we fast. However, if we eat a big meal right before sleeping, we’re not going to have autophagy.
Third, melatonin secretion increases soon after the onset of darkness. It peaks in the middle of the night, between 2 and 4 a.m., and gradually falls during the second half of the night. As aforementioned, melatonin can also boost autophagy.
Quality and timely sleep are also good for maintaining our natural immunity with the help of two other hormones that sleep helps to boost—growth hormones and endorphins. There are far more secrets behind sleep, which is a topic worthy of being addressed in another paper.
In other words, let us align with the sun’s cycle around the earth. Sleep as the sun sets, awaken as the sun rises, and we’ll be good!
Another healthy lifestyle component that can activate autophagy is sitting in meditation.
A study published in the journal Nature–Translational Psychiatry in 2016, followed 64 healthy women, half of whom were given a vacation, while the other half meditated. After one week, it was found that the meditators had significantly lower serum levels of Aβ40, which implies increased autophagy in brain nerve cells and a reduced risk of dementia.
This finding echoes the findings of a study published in the journal Neurobiology of Aging in 2007. The study compared the gray matter volume in the brains of meditators and non-meditators. It was discovered that the gray matter volume of the meditators did not shrink with age, but even increased, suggesting that meditation reverses the aging of, and damage to, the brain.
Meditators also showed great improvement in their ability to concentrate and in their response times, things which may help long COVID patients suffering from brain fog.
Studies on the beneficial health effects of exercise have traditionally focused on metabolic boosting, as well as promoting the functions of the respiratory and cardiovascular systems.
However, the potential autophagy-dependent beneficial effects of exercise are also robust. The recycling of cellular components by autophagy is an important factor involved in the beneficial responses to exercise.
Exercise positively regulates the autophagy capacity/flux of skeletal muscle via certain proteins and pathways.
Exercise-induced activation of autophagy in skeletal muscle has been shown to be influenced by transcriptional regulation of autophagy-related genes (ATGs).
The beneficial effects of exercise include the degradation of oxidatively damaged proteins and organelles, improved mitochondrial oxidative capacity, improved glucose regulation, protein synthesis, preservation of muscle strength and mass, and improved endurance exercise performance.
It was observed that treadmill exercise (8 weeks) in mice positively modulated the levels of autophagy-associated proteins, improved autophagy, reduced the number of toxic proteins (alpha-synuclein), and thus boosted neuroprotection.
Other studies have also shown that exercise training boosts autophagy-associated lysosomal pathways and promotes mitochondrial biogenesis in aged hippocampal neurons, indicating the benefit of potentially preventing neurodegenerative conditions and aging.
Patients with long COVID and post-vaccine symptoms frequently suffer from severe post-exertional fatigue with worsened symptoms after exercise. Problems with exercise in COVID-19 patients, particularly with the vaccine injured, have been terribly debilitating.
Therefore, we suggest light movements, such as walking, tai chi, yoga, or relaxation therapy. More robust exercises, such as intense aerobic exercises, may be too taxing.
Natural Molecules Boosting Autophagy
There are also a number of nature-derived molecules that can boost autophagy. Here we will introduce a few of them, including ivermectin, melatonin, resveratrol, spermidine, and terpene nutrients.
Ivermectin (IVM), originally derived from Japanese soil, is an FDA-approved anti-parasitic drug that has a broad-spectrum antiviral activity and inhibition against the SARS-CoV-2 virus.
In an in vitro cellular model, when ivermectin was added at 2 hours post-SARS-CoV-2 infection, there was a ~5000-fold reduction of viral genetic material at 48 hours.
Ivermectin binds to the spike protein and helps prevent its entry into our cells, reducing the burden of spike protein from the outset.
Furthermore, Ivermectin also induces autophagy through an intracellular signaling pathway named “AKT/mTOR.”
Melatonin is a pleiotropic molecule that not only reduces oxidative and cellular stress but also regulates the immune system and activates the autophagy pathway by reinforcing unfolded protein response (UPR) and unlocking autophagy blockage. This allows autophagosomes to bind to lysosomes, completing the process of autophagy, and decreasing viral replication.
Melatonin is a smart molecule. It differentially modulates autophagy and the related pathways in normal versus tumor trophoblast cells, being cytoprotective in normal cells, whilst increasing apoptosis in tumoral trophoblast cells.
Resveratrol (RSV) is a natural compound that has recently attracted much attention for its antioxidative effects on multiple diseases. Resveratrol reduces both apoptosis and inflammation. It is distinguished because it regulates several cellular processes that prevent cellular injury and increase viability.
RSV is naturally present in foods such as grapes, blueberries, and peanuts, to name a few.
In addition, resveratrol induces autophagy by inhibiting mTOR through multiple pathways, such as promoting the association between mTOR and DEPTOR, triggering the phosphorylation of Raptor via activating AMPK and directly inhibiting mTOR, and as a SIRT1 activator to active AMPK and directly inhibit mTOR.
As an inducer of autophagy, RSV has multiple beneficial effects in different pathologies, ranging from the energetic regulation of the cell (promoting ATP production) to the regulation of neural regeneration.
Spermidine is a naturally occurring polyamine that, like resveratrol, has anti-inflammatory and antioxidant properties. It preserves mitochondrial function and has been shown to reduce cardiovascular disease and prolong lifespan.
Spermidine plays a central role in cellular homeostasis and self-repairing mechanisms that promote macroautophagy/autophagy via directly inducing phagosome-lysosome fusion, helping induce eIF5a, which in turn, induces genes to start autophagy (ATG3 and TFEB) and improve mitochondrial respiration.
The polyamine pathway is highly conserved from bacteria to mammals.
Spermidine is prominently found in aged cheese, wheat germ, nuts, soybeans, mushrooms, broccoli, apples, and pears.
In addition to resveratrol and spermidine, there are other health-improving nutrients from plants that can promote autophagy.
In an article published in the journal Aging in 2021, Russian scientists found that terpenes extracted from Siberian fir trees could effectively activate autophagy.
After treating cells with terpenes for 24 hours, the percentage of cells containing autophagosomes (garbage bags) or autophagolysosomes (garbage processing stations) both increased significantly compared to the control group, and the number of autophagosomes contained in a single cell also increased.
Reduce Intake of Acid Blockers
Proton pump inhibitors (PPIs) should be avoided as they prevent the acidification of lysosomes and disrupt the autophagy pathway.
The spike protein has been reported to damage the mitochondrial functions of our epithelial cells, while PPIs also accelerate endothelial senescence. Therefore, PPIs should be used with caution for anyone suffering from long COVID or vaccine-related injuries.
The Human Body’s Potential
The prolonged pandemic has affected the human body in many ways, including putting tremendous stress on our neurological and mental health.
The body has enormous capabilities for self-healing and self-repair. Our approach is to help the body heal itself. There are a number of natural strategies we can employ to help boost our body’s autophagy process.
While different approaches may appear unrelated, they are actually interconnected with one another. A combination of different methods may have synergistic effects, and we may have to find an individualized way of combining these approaches, as each person’s body and the condition is unique.
By taking a holistic approach and understanding the interconnections among our endowed natural healing mechanisms, we may have a better chance of fundamentally improving our physical and mental health.